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The move by the Federal Highway Administration clears the way for the Texas Department of Transportation to begin buying property for right of way.
The parents of a 20-year-old Prairie View A&M University transfer student who died last month are suing the school and Phi Beta Sigma fraternity, among other defendants.
It shows Gov. Rick Perry leading Sen. Kay Bailey Hutchison by 12 points among Republicans.
There are four candidates, none of whom seems likely to get 50 percent.
Supporters hope passage of one will help create more top-tier universities.
Supporters hope passage of Proposition 4 will help create as many as seven more top tier universities in Texas.